We are excited to share our latest research published in Leukemia
This paper, by Dr. Alberto Hernández Sánchez, leverages the extensive data on the HARMONY Platform to explore how co-mutations influence prognosis in NPM1-mutated acute myeloid leukemia (AML). By analyzing large patient cohorts and applying refined genomic stratification, the study identifies clinically relevant co-mutational patterns and proposes a risk classification that could enhance decision-making—especially in transplant strategies.
This publication has emanated from research conducted with the support of the HARMONY Alliance Foundation and has been published as an Open Access publication. You can read the full piece of work on Nature on this link.
Why this matters
AML is a complex and heterogeneous blood cancer. Understanding how specific gene combinations affect outcomes helps clinicians tailor treatment strategies and ultimately improves patient care. This research exemplifies how collaborative data sharing and analytics can transform real-world evidence into actionable insights.
At the HARMONY Alliance Foundation, we are committed to driving innovation in hematologic malignancies through data-driven research, cross-institutional collaboration, and scalable scientific impact. We would like to thank all the researchers involved and their centres, as well as the patients who shared the data that made this study possible!
